Public Lab

CA 125

Rate: Rs. 1,100

Sample

This test is done on serum of the patient.

Serum can be stored for 24 hours at 2—8 C.For longer period store at -20 c.

Cancer antigen 125 (CA-125) A cell surface glycoprotein (high mol.wt) first identified in the mucinous adenocarcinome of ovary,also found in Adenocarcinoma of cervix, endometrium, gastrointestinal tract carcinoma and breast.

•This is produced by the the epithelial ovarian cancer cells

and not by the normal cells.But this is present in normal endometrial tissue, serous and mucinous uterine fluids.

•CA 125 measure the amount of this protein in the blood.

CA-125 is found on the surface of many ovarian cancer cells and 80 % of non-mucinous ( usually serous carcinoma ).

Rising titer indicate poor prognosis.

•It also can be found in other cancers and in small amounts in normal tissue.

Purpose

1.CA-125 is used as a tumor marker.

2.Most often, the CA-125 test is used to check how well treatment for ovarian cancer is working or to see if ovarian cancer has returned

3.It may be found in the cancer of Breast and liver cell carcinoma.It is also raised in pregnancy, cirrhosis and peritonitis.

High values

Noncancerous conditions

Some noncancerous conditions may cause high levels of CA-125.

1.These conditions include pelvic inflammatory disease (PID), endometriosis, uterine fibroids.

2.liver disease (such as hepatitis or cirrhosis).

3.pancreatitis,

4.The first trimester of pregnancy, the menstrual cycle,

Cancerous conditions with high values:

1.Ovarian cancer or cancer in the fallopian tubes.

2.The cancer of endometrium can cause high levels of CA-125.

3.Other types of cancer also may cause a high CA-125 level. These include cancer of the pancreas, stomach, esophagus, liver, breast, colon, or lung.

•In ovarian and endometrial carcinoma the persistently rising values indicate progressive disease or poor therapeutic response.While decline values indicate fovourable prognosis and good therapeutic response.

•Normal values does not rule out recurrence or the presence of extensive tumor.

Normal

Less than 35 U/mL in 99 % of female population.

Less tha 65 U/mL in 100 % of female poulation.